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Home > Treatment > Drug Dosing Toolkit > Odefsey

Edurant + tenofovir alafenamide + Emtriva (Odefsey)

Type of Drug: Fixed-Dose Combination
Fixed-dose combinations combine the most commonly prescribed doses of 2 or more medications into a single pill.

Approved adult dosing

Edurant 25 mg + tenofovir alafenamide 25 mg + Emtriva 200 mg in a single tablet

one tablet

  • Once daily



Notes on taking this medication

  • Take with a full meal (do not take without food)
  • Medicines for indigestion, heartburn, and ulcers (including medicines available over the counter) may block the body's absorption of Odefsey; check with your medical provider before using these medicines
  • Odefsey can interact with other drugs; consult your medical provider
  • Persons with kidney problems may need an adjustment to their doses of the component drugs, so may not be able to take this combination pill

Same possible side effects as


  • Depression, mood changes
  • Nausea
  • Rash

Tenofovir alafenamide

  • Gassiness; abdominal discomfort; nausea; diarrhea
  • Kidney impairment
  • Tenofovir alafenamide is active against hepatitis B, and stopping it can cause "flare-up" of hepatitis B


  • Skin discoloration (particularly in dark-skinned people)
  • Emtriva is active against hepatitis B, and stopping it can cause "flare-up" of hepatitis B

See accompanying chart: Tips for Common Side Effects

My doctor's instructions

Scroll over drug name to see other names for the drug.