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HIV Vaccine Development: Related Resources
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arrow imageGuidelines and Best Practices
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Updates
NIH Discontinues Immunizations in HIV Vaccine Study
Statement from the National Institutes of Health regarding termination of the HVTN 505 clinical trial; April 25, 2013.
Failure of latest HIV vaccine test: a 'huge disappointment'
News article from NPR; April 26, 2013.
Related Knowledge Base Chapters
Assays to Detect Host Immune Responses to HIV
Helen Horton, M. Juliana McElrath, July 2003.
Policy Issues in AIDS Vaccine Development
Chris Collins, February 2001.
Journal Articles
A brief history of the global effort to develop a preventive HIV vaccine
Esparza J. Vaccine. 2013 May 21.
Harnessing CD4+ T cell responses in HIV vaccine development
Streeck H, D'Souza MP, Littman DR, et al. Nat Med. 2013 Feb;19(2):143-9.
Accelerating the development of a safe and effective HIV vaccine: HIV vaccine case study for the Decade of Vaccines
Koff WC, Russell ND, Walport M, et al.
Recent advances in research of HIV infection: implications of viral and host genetics on treatment and prevention
Haaland RE, Johnson JA, Tang J. Public Health Genomics. 2013;16(1-2):31-6.
HIV vaccine development: strategies for preclinical and clinical investigation
Shapiro SZ. AIDS Res Hum Retroviruses. 2013 Mar 8.
In pursuit of an HIV vaccine: designing efficacy trials in the context of partially effective non-vaccine prevention modalities
Janes H, Gilbert P, Buchbinder S, et al. AIDS Res Hum Retroviruses. 2013 Apr 19.
The Thai Phase III HIV Type 1 Vaccine trial (RV144) regimen induces antibodies that target conserved regions within the V2 loop of gp120
Karasavvas N, Billings E, Rao M, et al. AIDS Res Hum Retroviruses. 2012 Nov;28(11):1444-57.
Rational design of vaccines for AIDS and influenza
Nabel GJ. Trans Am Clin Climatol Assoc. 2012;123:9-15; discussion 15-6.
HIV-1 vaccine trials: evolving concepts and designs
Sanou MP, De Groot AS, Murphey-Corb M, et al. Open AIDS J. 2012;6:274-88.
HIV vaccines: progress to date.
Munier CM, Andersen CR, Kelleher AD. Drugs. 2011 Mar 5;71(4):387-414.
Guidelines and Best Practices
Good Participatory Practice: Guidelines for Biomedical HIV Prevention Trials, 2011
UNAIDS. Guidelines to complement the companion document Ethical Considerations in Biomedical HIV Prevention Trials. [PDF, 3.1MB]
Ethical Considerations in Biomedical HIV Prevention Trials
UNAIDS, 2007 (additional guidance point added in 2012). [PDF, 868K]
Declaration of Helsinki: Ethical Principles for Medical Research Involving Human Subjects
World Medical Association, June 1964 (periodically amended).
Conference Reports and Proceedings
AIDS Vaccine Conference 2012
Conference page with program, abstracts, and webcasts. September 9-12, 2012; Boston.
Presentations, Interviews, and Roundtable Discussions
HVTN Trial Results and Implications for Future Research
A webinar featuring investigators Scott Hammer and Madgalena Sobieszczyk, who discuss the results of the HVTN 505 AIDS vaccine clinical trial and take questions. April 30, 2013.
Research Summaries
HIV Preventive Vaccine Clinical Trials
List from AIDSinfo.
HIV Therapeutic Vaccine Clinical Trials
List from AIDSinfo.
Online Books and Chapters
Immunobiology: The Immune System in Health and Disease
Charles Janeway, Paul Travers, Mark Walport, Mark Shlomchik, eds. Garland Science Publishing; 2001.
Clinician Support Tools
Preventative HIV Vaccine Trials
A chart from AVAC listing the ongoing vaccine trials, with key information such as phase, regimen, current status, and number of enrollees; April 2013. [PDF, 275KB]
Slide Sets
AIDS Vaccines: The Basics
An introductory slide set with basic concepts, an overview of research status and recent developments; AVAC; April 2013. [PPT, 4.82MB]
AIDS Vaccines: Then and Now
Graphical comparisons of numbers of AIDS vaccine trial sites, participants, and investment over the years; AVAC; May 2012. [PPT, 2.73MB]
Links
Organizations
Research
Bill and Melinda Gates Foundation: Global Health
Funds HIV/AIDS vaccine development initiatives.
FDA Center for Biologics Evaulation and Research
(CBER) U.S. regulatory agency that oversees vaccine products.
Global HIV Vaccine Enterprise
An alliance of independent organizations around the world dedicated to accelerating the development of a preventive HIV vaccine.
Harvard AIDS Institute
Vaccine research page.
HIV Vaccine Trials Network
(HVTN) International NIAID-sponsored preventive vaccine trials sites network.
IAVI Report Online
Newsletter on international AIDS vaccine research.
NIH Vaccine Research Center
Focus of research is on the development of vaccines for AIDS.
Pasteur Institute
A leading HIV vaccine research organization in France.
South African AIDS Vaccine Initiative
(SAAVI) A national body coordinating the research, development and testing of HIV/AIDS vaccines in South Africa.
Testes para Vacinas Anti-HIV
Portuguese-language web site provides information about HIV vaccines for the general public, and offers volunteers the opportunity to sign up for vaccine trials at the University of São Paulo, Brazil.
U.S. Military HIV Research Program
The U.S. Military HIV Research Program encompasses Army, Navy and Air Force medical centers, hospitals, and research institutes in the U.S. and around the globe. Research focus includes vaccine development and clinical trials.
U.S. National Institute of Allergy and Infectious Diseases, Division of AIDS
Part of the U.S. National Institutes of Health. Premier public research institution funding basic and applied research on AIDS vaccine development. Web site includes comprehensive overview of HIV/AIDS vaccine discovery, plus information on research funding opportunities and vaccine-related links.
Vaccine Research Center
Part of the NIH's National Institute of Allergy and Infectious Diseases (NIAID), the Dale and Betty Bumpers Vaccine Research Center (VRC) was established to facilitate research in vaccine development.
Advocacy
AIDS Vaccine Advocacy Coalition
(AVAC) Advocacy for developing HIV/AIDS vaccines. Site features Vaccine handbook, news articles, official reports, FAQs, and activist manifestos.
Capital Area Vaccine Effort
A volunteer panel of individuals from the general public and communities affected by AIDS. Assists and advises vaccine trials in the metropolitan Washington, DC area.
Global Alliance for Vaccines and Immunization
Works to expand access to existing vaccines in the developing world and accelerate research on needed vaccines, including HIV vaccines.
International AIDS Vaccine Initiative
(IAVI) Works to speed the development and distribution of preventive AIDS vaccines by funding research, mobilizing support through advocacy and education, and encouraging private sector participation in AIDS vaccine development.
National AIDS Trust (UK)
UK's leading policy development and advocacy AIDS organisation. Includes a prevention technologies annual update.
WHO-UNAIDS HIV Vaccine Initiative
(HVI) Advocacy, information, education, and policy dialogue.
Vaccine Company Pages
AlphaVax
VEE product.
Bavarian Nordic
Poxvirus (MVA) vector.
Chiron
DNA and peptide approaches.
Crucell
Adenoviral vectors.
Geovax
DNA plasmids and MVA vectors.
Progenics Pharmaceuticals, Inc.
Monoclonal antibodies and gp 140.
VaxGen
AIDSVAX gp120 subunit.
Clinical Trial Databases
AIDSinfo Vaccine Information
A service of the U.S. Department of Health and Human Services. Includes searchable listings of clinical trials for preventive and therapeutic HIV vaccines, as well as a glossary, HIV vaccine news, and links to related web sites.
HIV/SIV Vaccine Trials Database
A project of the Los Alamos National Laboratory.
International AIDS Vaccine Initiative (IAVI)
Works to speed the development and distribution of preventive AIDS vaccines by funding research, mobilizing support through advocacy and education, and encouraging private sector participation in AIDS vaccine development.
Document Collections
FDA Center for Biologics Evaulation and Research (CBER)
Vaccine publication guidance page.
HIV and Hepatitis.com
Reports on HIV vaccines.
The Body
Compilation of HIV vaccine articles.