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About the Database of Antiretroviral Drug Interactions
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Database Overview
Sources Reviewed
Abbreviations
Disclaimer
Contact
Database Overview

This database contains drug interactions (involving at least one antiretroviral drug) that the editors have found reported in published articles, abstracts from major conferences, or information presented to the U.S. Food and Drug Administration (generally reflected in product labeling). Studies demonstrating the absence of an interaction are also included. In addition to interactions demonstrated by data, interactions inferred from predicted mechanisms of drug metabolism are included when judged to be of potential clinical significance. Additive toxicities resulting or predicted from shared side-effect profiles are not included, unless a true pharmacokinetic interaction is thought to contribute (for information on additive toxicities, refer to HIV-Related Drugs with Overlapping Toxicities from the DHHS Adult & Adolescent Antiretroviral Treatment Guidelines). In vitro studies, results reported in brief letters, and animal studies are not generally included. Interactions between non-antiretroviral drugs are not included (for information on other types of interactions, refer to the Drug Information Links page).

Possible alternative agents listed represent potential options of which the editors are aware. They are not treatment recommendations, and are not intended to be exhaustive. Recommendations not to coadminister, to dose adjust, or to avoid a given combination reflect the opinions of the editors and may not apply to individual situations.

Sources Reviewed

In addition to product labeling, the following sources have been reviewed:

Journals:

AIDS
Annals of Internal Medicine
Annals of Pharmacotherapy
Antimicrobial Agents and Chemotherapy
Clinical Infectious Diseases
Clinical Pharmacology and Therapeutics
Journal of Acquired Immune Deficiency Syndromes
Journal of Clinical Pharmacology
Journal of Infectious Diseases
Lancet
New England Journal of Medicine
Pharmacotherapy

Conference Abstracts:

Conference on Retroviruses and Opportunistic Infections
International AIDS Conference
International Conference on HIV Treatment and Pathogenesis
International Workshop on Clinical Pharmacology of HIV Therapy
Interscience Conference on Antimicrobial Agents and Chemotherapy

Databases:

MICROMEDEX

Abbreviations
The following abbreviations are used in this database:
ARV: antiretroviral
AUC: area under the plasma concentration-versus-time curve
BID: twice per day
Cmax: peak plasma concentration
Cmin: minimum plasma concentration
CYP450: cytochrome P-450 enzyme complex
g: grams
INR: international normalized ratio (for prothrombin time)
kg: kilograms
M8: active metabolite of nelfinavir
mcg: micrograms
mg: milligrams
mL: milliliter
PI: HIV-1 protease inhibitor
Q8H: every 8 hours
Q12H: every 12 hours
QAM: each morning
QD: each day
QHS: at bedtime
QOD: every other day
SQ: subcutaneous
TID: three times per day
Disclaimer

The information contained in this database is intended for use by experienced physicians and pharmacists, who are advised to use it only in conjunction with other sources of information. The database is not intended to replace sound professional judgment in individual situations. Patients with concerns or questions should consult their physician regarding any change in treatment.

The contributors to this site have made every effort to provide information that is accurate and complete as of the date of publication. However, in view of the rapid changes occurring in medical science, as well as the possibility of human error, this site may contain technical inaccuracies, typographical or other errors. Users are advised to recheck the information contained herein with the original source before applying it to patient care. Members of the lay public using this site are advised to consult with a physician regarding personal medical care.

The information contained herein is provided "as is" and without warranty of any kind. The contributors to this site, including HIV InSite and the University of California San Francisco, disclaim responsibility for any errors or omissions or for results obtained from the use of information contained herein.

Contact

Please contact us with suggestions or comments at: hivinsite@ucsf.edu.