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Darunavir Once-Daily Dosing for Children

The FDA recently approved revisions to the pediatric dosing recommendations for darunavir tablets and oral suspension. Once-daily dosing of darunavir + ritonavir is recommended for children 3 years of age and older, and >10 kg in weight, who are treatment naive or whose HIV virus does not have darunavir-associated resistance mutations. Dosage is weight based; specific recommendations are included in the package label, available at the Drugs@FDA portal.