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Home > Treatment > HIV Meds Quarterly > Summer 2009 > ARV Updates
Updates to the Database of ARV Drug Interactions
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HIV Meds Quarterly Research Brief
Summer 2009
Susa Coffey, MD, HIV InSite Medical Editor
Ian R. McNicholl, PharmD, BCPS (Added Qualifications-Infectious Diseases), HIV InSite Pharmacy Editor
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The following table summarizes recent additions to the HIV InSite Database of Antiretroviral Drug Interactions. For a full description of the updates, including references to the studies from which the data were derived, click on a specific drug name in the table below and search for the interacting agent.

New ARV Interactions (April-July 2009)
Drug OneDrug TwoClinical EffectsMechanismsManagement
Source: McNicholl I. HIV InSite Database of Antiretroviral Drug Interactions. University of California San Francisco: Center for HIV Information; 2009
TenofovirEtravirineNo dosage adjustment necessary
NevirapineFluconazolePossibly ↑ nevirapine effectsInhibition of CYP450 3A4 by fluconazoleNo dosage adjustment necessary
AtazanavirSimvastatin↑ simvastatin effects (eg, myopathy, rhabdomyolysis)Inhibition of CYP450 3A4 by atazanavirDo not coadminister

Alternative agents:
Atorvastatin (low dose); pravastatin

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