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Database of Antiretroviral Drug Interactions

Interactions with Ethanol (Alcohol, Ethanol, Wine, Liquor, Beer, Spirits) and Antiretrovirals

Antiretroviral (ARV)Dose of ARVDose of EthanolEffect on ARV LevelsEffect on Ethanol LevelsPotential Clinical EffectsMechanism of InteractionManagement
Abacavir212, 66
600 mg QD0.7 g/kg body weightAbacavir AUC: increased 41%; half-life: increased 26%No significant change-Decreased abacavir metabolism by alcohol dehydrogenase

No dose adjustment necessary

- - - - Propylene glycol toxicity (eg, acidosis, CNS depression)Inhibition of alcohol and aldehyde dehydrogenase metabolism of propylene glycol by alcohol

Use of alcoholic beverages is not recommended with amprenavir oral solution

Alternative Agents:
Amprenavir capsules

"-" indicates that there are no data available
 66:Ziagen [package insert]. Research Triangle Park, NC: GlaxoWellcome Inc.; Sept 2005.
 211:Agenerase Oral Solution [package insert]. Research Triangle Park, NC: Glaxo Wellcome Inc; 2004.
 212:McDowell JA, Chittick GE, Stevens CP, et al. Pharmacokinetic interaction of abacavir (1592U89) and ethanol in human immunodeficiency virus-infected adults. Antimicrob Agents Chemother 2000;44:1686-90.