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Database of Antiretroviral Drug Interactions

Interactions with Azithromycin and Antiretrovirals

Antiretroviral (ARV)Dose of ARVDose of AzithromycinEffect on ARV LevelsEffect on Azithromycin LevelsPotential Clinical EffectsMechanism of InteractionManagement
Efavirenz90
(EFV)(Sustiva)
400 mg x 7 days600 mg x 1 doseNo significant changeAzithromycin AUC: no significant change; Cmax: increased 22%- -

No dose adjustment necessary

Indinavir330
(IDV)(Crixivan)
800 mg TID1200 mg x 1 doseNo significant change- - -

No dose adjustment necessary

"-" indicates that there are no data available
 90:Sustiva [package insert]. Princeton, NJ: Bristol-Myers Squibb Company; Dec 2011.
 330:Foulds G, LaBoy-Goral L, Wei GCG, et al. The effect of azithromycin on the pharmacokinetics of indinavir. J Clin Pharmacol. 1999;39:842-46.