University of California, San Francisco Logo

University of California, San Francisco | About UCSF | Search UCSF | UCSF Medical Center

Home > Treatment > Interactions
Database of Antiretroviral Drug Interactions

All Interactions with Desipramine (Norpramin)

Coadministered DrugDose of DrugDose of DesipramineEffect on Drug LevelsEffect on Desipramine LevelsPotential Clinical EffectsMechanism of InteractionManagement
Elvitegravir/cobicistat623
(Genvoya, Stribild)
150 mg cobicistat50 mg-Desipramine AUC: increased 65%Increased desipramine effects-

Initiate low dose desipramine and titrate dose according to efficacy and adverse effects.

Elvitegravir/ritonavir-boosted protease inhibitor
---Expected increase in desipramine levelsIncreased risk of desipramine adverse effects-

Initiate lowest dose of desipramine and titrate according to efficacy, adverse effects and/or levels

Nelfinavir260
(NFV)(Viracept)
- - - May increase desipramine levelsIncreased desipramine effects (eg, dry mouth, dizziness, urinary retention)Inhibition of CYP450 2D6 by nelfinavir

Monitor and adjust desipramine as indicated

Ritonavir260
(RTV)(Norvir)
- - - Desipramine clearance: decreased 59%Increased desipramine effects (eg, dry mouth, dizziness, urinary retention)Inhibition of CYP450 2D6 by ritonavir

Monitor and adjust desipramine as indicated

"-" indicates that there are no data available
 260:von Moltke LL, Greenblatt DJ, Duan SX, et al. Inhibition of desipramine hydroxylation (Cytochrome P450-2D6) in vitro by quinidine and by viral protease inhibitors: relation to drug interactions in vivo. J Pharm Sci 1998;87:1184-9.
 623:Stribild [package insert]. Foster City, CA: Gilead Sciences, Inc.; August 2012.