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Home > Treatment > Drug Dosing Toolkit > Trizivir

Trizivir (AZT + Epivir + Ziagen)

Type of Drug: Fixed-Dose Combination

Fixed-dose combinations combine the most commonly prescribed doses of more than 1 medication into a single pill.

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Approved adult dosing

AZT 300 mg + Epivir 150 mg + Ziagen 300 mg in a single tablet

one tablet, two times a day

  • Morning



  • Evening



Notes on taking this medication

  • No food restrictions, can take with or without food
  • Do not take Trizivir with Zerit
  • Before taking Trizivir, you should be tested to see if you are at risk of an allergic reaction to the Ziagen component. The test is a blood test for a genetic marker called HLA B5701. If you are positive for HLA B5701, or have a history of allergy to abacavir (Ziagen, Epzicom) you cannot take Trizivir.
  • Persons with kidney problems may need an adjustment to their doses of the component drugs, and have to take them separately, not as one pill

Same side effects as


  • Nausea; stomach discomfort; headache
  • Symptoms of anemia (low red blood cell count): fatigue; shortness of breath
  • More rarely: muscle wasting; neutropenia (low white blood cell count)
  • Changes in body-fat distribution


  • Side effects are rare but include headaches and general sense of feeling ill
  • Epivir is active against hepatitis B, and stopping it can cause "flare-up" of hepatitis B


  • Mild nausea; vomiting; diarrhea; loss of appetite
  • Rash

See accompanying chart: Tips for Common Side Effects

My doctor's instructions

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