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Tivicay + Epivir + Ziagen (Triumeq)

Type of Drug: Fixed-Dose Combination
Fixed-dose combinations combine the most commonly prescribed doses of 2 or more medications into a single pill.

Approved adult dosing

Tivicay 50 mg + Epivir 300 mg + Abacavir 600 mg in a single tablet

One Triumeq once daily

  • Once daily



Notes on taking this medication

  • No food restrictions; you can take Triumeq with or without food.
  • Before taking Triumeq, you should be tested to see if you are at risk of a serious allergic reaction to the Ziagen component. The test is a blood test for a genetic marker called HLA B5701.
  • Do not take if you are positive for HLA B5701 or allergic to abacavir (Ziagen). Tell your pharmacist if your provider tells you that you are "allergic" to Epzicom or Ziagen.
  • Triumeq can interact with other drugs; consult your medical provider.
  • Antacids, laxatives, mineral supplements, and other compounds that contain calcium, magnesium, aluminum, or iron can decrease levels of Tivicay if they are taken close in time to each other. Ask your provider whether or how you can take these compounds with Tivicay.
  • Persons with kidney problems may need an adjustment to their doses of the component drugs, so may not be able to take this combination pill.

Possible side effects

  • Triumeq has not been studied during pregnancy; tell your medical provider if you become pregnant while taking this drug

See accompanying chart: Tips for Common Side Effects

Same possible side effects as


  • Usually well tolerated; may cause nausea; sleep disturbance; mood disturbance; headache; muscle aches; rash


  • Side effects are rare but include headaches and general sense of feeling ill
  • Epivir is active against hepatitis B, and stopping it can cause "flare-up" of hepatitis B


  • Mild nausea; vomiting; diarrhea; loss of appetite
  • Rash
  • Hypersensitivity reaction
  • Caution! Ziagen can cause a serious allergic reaction that includes at least 2 of the following: fever, malaise, severe nausea, diarrhea, abdominal pain, sore throat, cough, shortness of breath, and rash. Symptoms usually begin within 6 weeks of starting medication. Before taking Ziagen, you should be tested for HLA B5701.

    If you think you are having an allergic reaction, call your doctor at once. If allergic, you will have to stop Ziagen and never take it again. Starting it again can cause serious illness or death. Make sure you tell your pharmacist if you are allergic to Ziagen.

See accompanying chart: Tips for Common Side Effects

My doctor's instructions

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