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Darunavir + cobicistat + tenofovir alafenamide + emtricitabine (Symtuza)

Type of Drug: Fixed-Dose Combination
Fixed-dose combinations combine the most commonly prescribed doses of 2 or more medications into a single pill.

Approved adult dosing

Darunavir (Prezista) 800 + cobicistat 150 mg + tenofovir alafenamide 10 mg + emtricitabine (Emtriva) 200 mg in a single tablet

one tablet once a day

  • Atripla

    Symtuza

Notes on taking this medication

  • Take with food
  • Darunavir + cobicistat + tenofovir alafenamide + emtricitabine (Symtuza) interacts with many other drugs; consult your medical provider
  • Persons with kidney problems may need an adjustment to their doses of the component drugs, so may not be able to take this combination pill

Same possible side effects as

Darunavir (Prezista)

  • Nausea; diarrhea; stomach discomfort
  • Rash
  • Liver inflammation and increased liver enzyme levels
  • Elevations in cholesterol and triglycerides
  • Elevated blood sugar
  • Persons who are allergic to sulfa drugs may be allergic to darunavir

Cobicistat

  • Nausea, diarrhea
  • Headache
  • Fatigue
  • Elevation in blood creatinine levels (this is used to assess kidney function; your provider will monitor creatinine)

Tenofovir alafenamide (TAF)

  • Gassiness; abdominal discomfort; nausea; diarrhea
  • Possible kidney impairment
  • TAF is active against hepatitis B, and stopping it can cause "flare-up" of hepatitis B

Emtricitabine (Emtriva)

  • Skin discoloration (particularly in dark-skinned people)
  • Headache; diarrhea; nausea
  • Emtricitabine is active against hepatitis B, and stopping it can cause "flare-up" of hepatitis B

See accompanying chart: Tips for Common Side Effects

My doctor's instructions

Contents
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