University of California, San Francisco Logo

University of California, San Francisco | About UCSF | Search UCSF | UCSF Medical Center

Home > Treatment > Drug Dosing Toolkit > Prezista

Prezista (darunavir, TMC-114)

Type of Drug: Protease Inhibitor
Once HIV has infected a cell and made copies of itself, it uses an enzyme called protease to process itself correctly so it can be released from the cell to infect other cells. Protease inhibitors work by blocking that enzyme.
gray line
transparent gif

Approved adult dosing

For those whose HIV virus has darunavir-associated resistance mutations: one 600 mg tablet Prezista + one 100 mg tablet or capsule Norvir, two times a day

  • Morning

    Prezista 600

    Prezista 600 mg

    +
    Norvir 100

    Norvir

  • Evening

    Prezista 600

    Prezista 600 mg

    +
    Norvir 100

    Norvir

For those who have NEVER taken antiretroviral drugs or whose HIV has no resistance to darunavir: one 800 mg tablet Prezista + one 100 mg tablet or capsule Norvir, once a day

  • Daily

    no image available

    Prezista 800 mg

    +
    Norvir 100

    Norvir

Notes on taking this medication

  • Must take Prezista with Norvir; it is effective only with the use of Norvir
  • Must take with food
  • Prezista interacts with many other drugs; persons using Prezista with those drugs may need an adjustment to their dose of Prezista or the other drugs; consult your medical provider

Side effects

  • Nausea; diarrhea; stomach discomfort
  • Rash
  • Liver inflammation and increased liver enzyme levels
  • Elevations in cholesterol and triglycerides
  • Elevated blood sugar
  • Abnormal accumulation of body fat
  • Persons who are allergic to sulfa drugs may be allergic to Prezista

See accompanying chart: Tips for Common Side Effects

My doctor's instructions

transparent gif
Contents
transparent gifScroll over drug name to see other names for the drug.
transparent gif
transparent gif
transparent gif