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Home > Treatment > Drug Dosing Toolkit > Prezista

Prezista (darunavir)

Type of Drug: Protease Inhibitor
Once HIV has infected a cell and made copies of itself, it uses an enzyme called protease to process itself correctly so it can be released from the cell to infect other cells. Protease inhibitors work by blocking that enzyme.
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Approved adult dosing

For those who have NEVER taken antiretroviral drugs: one 800 mg tablet Prezista + one 100 mg tablet Norvir or one 150 mg tablet Tybost, once a day

  • Daily

    image of a 800 mg Prezista pill

    Prezista 800 mg

    +
    Norvir tablet

    Norvir

    or
    Tybost

    Tybost

For those whose HIV virus has darunavir-associated resistance mutations: one 600 mg tablet Prezista + one 100 mg tablet Norvir, two times a day

  • Morning

    Prezista 600

    Prezista 600 mg

    +
    Norvir tablet

    Norvir

  • Evening

    Prezista 600

    Prezista 600 mg

    +
    Norvir tablet

    Norvir

Notes on taking this medication

  • Must take Prezista with Norvir or Tybost; it is effective only with one of these
  • Must take with food
  • Prezista interacts with many other drugs; persons using Prezista with those drugs may need an adjustment to their dose of Prezista or the other drugs; consult your medical provider

Side effects

  • Nausea; diarrhea; stomach discomfort
  • Rash
  • Liver inflammation and increased liver enzyme levels
  • Elevations in cholesterol and triglycerides
  • Elevated blood sugar
  • Abnormal accumulation of body fat
  • Persons who are allergic to sulfa drugs may be allergic to Prezista

See accompanying chart: Tips for Common Side Effects

My doctor's instructions

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Contents
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