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Home > Treatment > Drug Dosing Toolkit > Prezista

Prezista (darunavir, TMC-114)

Type of Drug: Protease Inhibitor
Once HIV has infected a cell and made copies of itself, it uses an enzyme called protease to process itself correctly so it can be released from the cell to infect other cells. Protease inhibitors work by blocking that enzyme.
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Approved adult dosing

For those who have taken antiretroviral drugs before: one 600 mg tablet Prezista + one 100 mg capsule or tablet Norvir, two times a day

  • Morning

    Prezista 600

    Prezista 600 mg

    +
    Norvir 100

    Norvir

  • Evening

    Prezista 600

    Prezista 600 mg

    +
    Norvir 100

    Norvir

For those who have NEVER taken antiretroviral drugs: two 400 mg tablets Prezista + one 100 mg capsule or tablet Norvir, once a day

  • Daily

    Prezista 400Prezista 400

    Prezista 400 mg each

    +
    Norvir 100

    Norvir

Notes on taking this medication

  • Must take Prezista with Norvir; it is approved only with the use of Norvir
  • Must take with food
  • Prezista interacts with many other drugs; persons using Prezista with those drugs may need an adjustment to their dose of Prezista or the other drugs; consult your medical provider

Side effects

  • Nausea; diarrhea; stomach discomfort
  • Rash
  • Liver inflammation and increased liver enzyme levels
  • Elevations in cholesterol and triglycerides
  • Elevated blood sugar
  • Abnormal accumulation of body fat
  • Persons who are allergic to sulfa drugs may be allergic to Prezista

See accompanying chart: Tips for Common Side Effects

My doctor's instructions

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Contents
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