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Home > Treatment > Drug Dosing Toolkit > Isentress

raltegravir (Isentress)

Type of Drug: Integrase Inhibitor
Integrase inhibitors work by blocking an enzyme (HIV integrase) that the virus needs in order to make more virus.

Approved adult dosing

one 400 mg tablet Isentress, two times a day

  • Morning



  • Evening



Two 600 mg tablet Isentress HD, once a day

  • Daily

    Isentress HDIsentress HD

    Isentress HD 600 mg

Notes on taking this medication

  • Isentress interacts with certain antacids and laxatives, and with calcium and iron supplements; check with your medical provider before using these.
  • Isentress interacts with certain tuberculosis medications. If you're being treated for TB or MAC, let your HIV provider know.

Possible side effects

  • Usually well tolerated; may cause nausea; diarrhea; headache; muscle aches; rash
  • Contact your doctor promptly if you experience unexplained muscle pain, tenderness, or weakness

See accompanying chart: Tips for Common Side Effects

My doctor's instructions

Scroll over drug name to see other names for the drug.