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Home > Treatment > Drug Dosing Toolkit > Epzicom

Epzicom (Epivir + Ziagen)

Type of Drug: Fixed-Dose Combination

Fixed-dose combinations combine the most commonly prescribed doses of more than 1 medication into a single pill.

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Approved adult dosing

Epivir 300 mg + Ziagen 600 mg in a single tablet

one tablet, once a day

  • Daily

    Epzicom (Ziagen + Epivir)


Notes on taking this medication

  • No food restrictions, can take with or without food
  • Do not take Epzicom with Emtriva
  • Before taking Epzicom, you should be tested to see if you are at risk of a serious allergic reaction to the Ziagen component. The test is a blood test for a genetic marker called HLA B5701.
  • Do not take if you are positive for HLA B5701 or allergic to abacavir (Ziagen). Tell your pharmacist if your provider tells you that you are "allergic" to Epzicom or Ziagen.
  • Persons with kidney problems may need an adjustment to their doses of the component drugs, and have to take them separately, not as a single pill

Same side effects as


  • Side effects are rare but include headaches and general sense of feeling ill
  • Epivir is active against hepatitis B, and stopping it can cause "flare-up" of hepatitis B


  • Mild nausea; vomiting; diarrhea; loss of appetite
  • Rash

See accompanying chart: Tips for Common Side Effects

My doctor's instructions

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