University of California, San Francisco Logo

University of California, San Francisco | About UCSF | Search UCSF | UCSF Medical Center

Home > Treatment > Drug Dosing Toolkit > Combivir

Combivir (AZT + Epivir)

Type of Drug: Fixed-Dose Combination

Fixed-dose combinations combine the most commonly prescribed doses of more than 1 medication into a single pill.

Approved adult dosing

AZT 300 mg + Epivir 150 mg in a single tablet

one tablet, two times a day

  • Morning



  • Evening



Note: Generic formulations are available; these generic pills may have different shapes and colors than the one shown above.

Notes on taking this medication

  • No food restrictions, can take with or without food
  • Do not take Combivir with Emtriva or Zerit
  • Persons with kidney problems may need an adjustment to their doses of the component drugs, and have to take them separately, not as a single pill

Same side effects as

AZT (Retrovir)

  • Nausea; stomach discomfort; headache
  • Symptoms of anemia (low red blood cell count): fatigue; shortness of breath
  • More rarely: muscle wasting; neutropenia (low white blood cell count)
  • Changes in body-fat distribution


  • Side effects are rare but include headaches and general sense of feeling ill
  • Epivir is active against hepatitis B, and stopping it can cause "flare-up" of hepatitis B

See accompanying chart: Tips for Common Side Effects

My doctor's instructions

Scroll over drug name to see other names for the drug.