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Policy Issues in AIDS Vaccine Development: Related Resources
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Related Knowledge Base Chapters
Assays to Detect Host Immune Responses to HIV
Helen Horton, M. Juliana McElrath, July 2003.
Journal Articles
Predicting the impact of a partially effective HIV vaccine and subsequent risk behavior change on the heterosexual HIV epidemic in low- and middle-income countries: A South African example
Andersson KM, Owens DK, Vardas E, Gray GE, McIntyre JA, Paltiel AD. J Acquir Immune Defic Syndr. 2007 Sep 1;46(1):78-90. Includes commentary from the UCSF Institute for Global Health.
Enrolling Women into HIV Preventive Vaccine Trials: An Ethical Imperative but a Logistical Challenge
Mills E, Nixon S, Singh S, Dolma S, Nayyar A, Kapoor S. PLoS Biol. 2006 Feb 21;3(3):e94.
A sound rationale needed for phase III HIV-1 vaccine trials
Burton DR, Desrosiers RC, Doms RW, Feinberg MB, Gallo RC, Hahn B, Hoxie JA, Hunter E, Korber B, Landay A, Lederman MM, Lieberman J, McCune JM, Moore JP, Nathanson N, Picker L, Richman D, Rinaldo C, Stevenson M, Watkins DI, Wolinsky SM, Zack JA. Science. 2004 Jan 16;303(5656):316.
See also the responses to this article:
bullet.gifSupport for the RV144 HIV vaccine trial
AIDS Vaccine Advocacy Coalition. Science. 2004 Jul 9;305(5681):177-80; author reply 177-80.
bullet.gifThailand's Prime-Boost HIV Vaccine Phase III
Trinvuthipong C. Science. 2004 Feb 13;303(5660):954-5.
bullet.gifHIV vaccine trial justified
McNeil JG, Johnston MI, Birx DL, Tramont EC. Science. 2004 Feb 13;303(5660):961.
The need for a global HIV vaccine enterprise
Klausner RD, Fauci AS, Corey L, Nabel GJ, Gayle H, Berkley S, Haynes BF, Baltimore D, Collins C, Douglas RG, Esparza J, Francis DP, Ganguly NK, Gerberding JL, Johnston MI, Kazatchkine MD, McMichael AJ, Makgoba MW, Pantaleo G, Piot P, Shao Y, Tramont E, Varmus H, Wasserheit JN. Science. 2003 Jun 27;300(5628):2036-9.
HIV T cell vaccines: the importance of clades
McMichael A, Mwau M, Hanke T. Vaccine. 2002 May 6;20(15):1918-21.
HIV vaccine strategies
Nabel GJ. Vaccine. 2002 May 6;20(15):1945-7.
New hope for an AIDS vaccine
Robinson HL. Nat Rev Immunol. 2002 Apr;2(4):239-50.
Guidelines and Best Practices
Ethical Considerations in HIV Preventive Vaccine Research - UNAIDS Guidance Document
UNAIDS, April 2004. [PDF, 900K] Also in French, Spanish, and Russian.
Declaration of Helsinki: Ethical Principles for Medical Research Involving Human Subjects
World Medical Association, June 1964 (periodically amended).
Policy Reports, Papers, and Briefs
AVAC Report 2007 - Resetting the Clock
AIDS Vaccine Advocacy Coalition, August 2007. [PDF, 3MB] Download individual chapters on the AVAC Web site.
AIDS Vaccine Blueprint 2006: Actions to Strengthen Global Research and Development
International AIDS Vaccine Initiative, 2006. [PDF, 2.1MB]
Advanced Market Commitments: Helping to Accelerate AIDS Vaccine Development
International AIDS Vaccine Initiative, November 2005. [PDF, 160K]
Estimating the Global Impact of an AIDS Vaccine
International AIDS Vaccine Initiative, October 2005. [PDF, 125K]
Gender in AIDS Vaccine Trials
International AIDS Vaccine Initiative, November 2004. [PDF, 209K]
Online Books and Chapters
Immunobiology: The Immune System in Health and Disease
Charles Janeway, Paul Travers, Mark Walport, Mark Shlomchik, eds. Garland Science Publishing; 2001.
Patient and Community Education
Introduction to AIDS Vaccines
A media presentation introducing the world of AIDS vaccine research. AIDS Vaccine Clearinghouse (www.aidsvaccineclearinghouse.org), February 2007.
AIDS Vaccine Handbook: Global Perspectives, 2nd Edition
AIDS Vaccine Advocacy Coalition, December 2005.
Links
Organizations
Research
Bill and Melinda Gates Foundation: Global Health
Funds HIV/AIDS vaccine development initiatives.
FDA Center for Biologics Evaulation and Research
(CBER) U.S. regulatory agency that oversees vaccine products.
Global HIV Vaccine Enterprise
An alliance of independent organizations around the world dedicated to accelerating the development of a preventive HIV vaccine.
Harvard AIDS Institute
Vaccine research page.
HIV Vaccine Trials Network
(HVTN) International NIAID-sponsored preventive vaccine trials sites network.
IAVI Report Online
Newsletter on international AIDS vaccine research.
Pasteur Institute
A leading HIV vaccine research organization in France.
South African AIDS Vaccine Initiative
(SAAVI) A national body coordinating the research, development and testing of HIV/AIDS vaccines in South Africa.
Testes para Vacinas Anti-HIV
Portuguese-language web site provides information about HIV vaccines for the general public, and offers volunteers the opportunity to sign up for vaccine trials at the University of São Paulo, Brazil.
U.S. Centers for Disease Control and Prevention, HIV Vaccine Unit
CDC vaccine development page.
U.S. Military HIV Research Program
The U.S. Military HIV Research Program encompasses Army, Navy and Air Force medical centers, hospitals, and research institutes in the U.S. and around the globe. Research focus includes vaccine development and clinical trials.
U.S. National Institute of Allergy and Infectious Diseases, Division of AIDS
Part of the U.S. National Institutes of Health. Premier public research institution funding basic and applied research on AIDS vaccine development. Web site includes comprehensive overview of HIV/AIDS vaccine discovery, plus information on research funding opportunities and vaccine-related links.
Vaccine Research Center
Part of the NIH's National Institute of Allergy and Infectious Diseases (NIAID), the Dale and Betty Bumpers Vaccine Research Center (VRC) was established to facilitate research in vaccine development.
Advocacy
AIDS Vaccine Advocacy Coalition
(AVAC) Advocacy for developing HIV/AIDS vaccines. Site features Vaccine handbook, news articles, official reports, FAQs, and activist manifestos.
Capital Area Vaccine Effort
A volunteer panel of individuals from the general public and communities affected by AIDS. Assists and advises vaccine trials in the metropolitan Washington, DC area.
Global Alliance for Vaccines and Immunization
Works to expand access to existing vaccines in the developing world and accelerate research on needed vaccines, including HIV vaccines.
International AIDS Vaccine Initiative
(IAVI) Works to speed the development and distribution of preventive AIDS vaccines by funding research, mobilizing support through advocacy and education, and encouraging private sector participation in AIDS vaccine development.
National AIDS Trust (UK)
UK's leading policy development and advocacy AIDS organisation. Includes a prevention technologies annual update.
WHO-UNAIDS HIV Vaccine Initiative
(HVI) Advocacy, information, education, and policy dialogue.
Vaccine Company Pages
AlphaVax
VEE product.
Bavarian Nordic
Poxvirus (MVA) vector.
Chiron
DNA and peptide approaches.
Crucell
Adenoviral vectors.
Geovax
DNA plasmids and MVA vectors.
Merck
Adenoviral vectors.
Progenics Pharmaceuticals, Inc.
Monoclonal antibodies and gp 140.
Sanofi Pasteur
ALVAC canarypox vector.
Targeted Genetics Corporation
Adeno-associated virus (AAV) product.
VaxGen
AIDSVAX gp120 subunit.
Wyeth
DNA plasmid and peptide vaccines.
Clinical Trial Databases
AIDSinfo Vaccine Information
A service of the U.S. Department of Health and Human Services. Includes searchable listings of clinical trials for preventive and therapeutic HIV vaccines, as well as a glossary, HIV vaccine news, and links to related web sites.
HIV/SIV Vaccine Trials Database
A project of the Los Alamos National Laboratory.
International AIDS Vaccine Initiative (IAVI)
Works to speed the development and distribution of preventive AIDS vaccines by funding research, mobilizing support through advocacy and education, and encouraging private sector participation in AIDS vaccine development.
Document Collections
FDA Center for Biologics Evaulation and Research (CBER)
Vaccine publication guidance page.
HIV and Hepatitis.com
Reports on HIV vaccines.
The Body
Compilation of HIV vaccine articles.