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Metabolic Complications of HIV Therapy: Related Resources
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Related Knowledge Base Chapters
Overview of Antiretroviral Drugs
Laurence Peiperl, Susa Coffey
HIV-Associated Wasting
Kathleen Mulligan, Morris Schambelan, November 2003.
Side Effects of Antiretroviral Drugs: Related Resources
Journal Articles
Metabolic complications and treatment of perinatally HIV-infected children and adolescents
Barlow-Mosha L, Eckard AR, McComsey GA, et al. J Int AIDS Soc. 2013 Jun 18;16:18600.
Predicting the short-term risk of diabetes in HIV-positive patients: the Data Collection on Adverse Events of Anti-HIV Drugs (D:A:D) study
Petoumenos K, Worm SW, Fontas E, et al; D:A:D Study Group. J Int AIDS Soc. 2012 Oct 10;15(2):17426.
Body composition and metabolic changes in HIV-infected patients
Stanley TL, Grinspoon SK. J Infect Dis. 2012 Jun;205 Suppl 3:S383-90. Review.
HIV medications: an update and review of metabolic complications
Hester EK. Nutr Clin Pract. 2012 Feb;27(1):51-64. Review.
Severe malnutrition and metabolic complications of HIV-infected children in the antiretroviral era: clinical care and management in resource-limited settings
Musoke PM, Fergusson P. Am J Clin Nutr. 2011 Dec;94(6):1716S-1720S. Review.
Management of the metabolic effects of HIV and HIV drugs
Brown TT, Glesby MJ. Nat Rev Endocrinol. 2011 Sep 20;8(1):11-21. Review.
The prevalence and pathogenesis of diabetes mellitus in treated HIV-infection
Paik IJ, Kotler DP. Best Pract Res Clin Endocrinol Metab. 2011 Jun;25(3):469-78. Review.
HIV infection, body composition changes and related metabolic complications: contributing factors and evolving management strategies
Falutz J. Curr Opin Clin Nutr Metab Care. 2011 May;14(3):255-60. Review.
Dyslipidemia and its treatment in HIV infection
Grunfeld C. Top HIV Med. 2010 Aug-Sep;18(3):112-8. Review.
Switching antiretroviral therapy to minimize metabolic complications
Lake JE, Currier JS. HIV Ther. 2010 Nov;4(6):693-711.
Metabolic outcomes in a randomized trial of nucleoside, nonnucleoside and protease inhibitor-sparing regimens for initial HIV treatment
Haubrich RH, Riddler SA, DiRienzo AG, et al; AIDS Clinical Trials Group (ACTG) A5142 Study Team. AIDS. 2009 Jun 1;23(9):1109-18.
Integrating Nutrition Therapy into Medical Management of Human Immunodeficiency Virus
Clinical Infectious Diseases (supplement), April 1, 2003. Special issue of CID, with articles devoted to HIV-related nutritional issues and metabolic abnormalities.
Guidelines and Best Practices
Management of Metabolic Complications Associated with Antiretroviral Therapy for HIV-1 Infection
Recommendations of an International AIDS Society-USA Panel, JAIDS, November 1, 2002.
Guidelines for the Evaluation and Management of Dyslipidemia in Human Immunodeficiency Virus (HIV)-Infected Adults Receiving Antiretroviral Therapy: Recommendations of the HIV Medicine Association of the Infectious Disease Society of America and the Adult AIDS Clinical Trials Group
Clinical Infectious Diseases 2003;37:613-627.
Conference Reports and Proceedings
Complications of HIV Disease, Viral Hepatitis, and Antiretroviral Therapy
Anne F. Luetkemeyer, Diane V. Havlir, Judith S. Currier. Topics in Antiviral Medicine, International Antiviral Society-USA, April/May 2013. Highlights of the 20th Conference on Retroviruses and Opportunistic Infections; Atlanta; March 3-6, 2013. [PDF, 531K]
Presentations, Interviews, and Roundtable Discussions
Metabolic Complications of HIV (and Antiretroviral Therapy)
New York State Department of Health AIDS Institute, Clinical Education Initiative; November 2012.

An online video learning module presented by Dr. Marshall Glesby, MD, PhD.

Co-Morbidities and Metabolic Complications in HIV
A 20-minute video presentation of a panel discussion at the 19th Conference on Retroviruses and Opportunistic Infections; March 5-8, 2012; Seattle. Panelists include Michael Dubé, MD; Edgar Turner Overton, MD; David Alain Wohl, MD; and Ronald T. Mitsuyasu, MD. Moderated by Jeff Taylor. From the IFARAblog.org website.
Metabolic Complications and Aging in HIV
New England AIDS Education and Training Center; September 2011. [PDF, 2.73MB]

A presentation given by Steven Grinspoon, MD, at the 6th National Conference on HIV/AIDS and Aging Symposium in Boston.

Online Books and Chapters
A Helpful Guide to HIV and Metabolic Complications
U.S. Department of Health and Human Services, National Institute of Allergy and Infectious Diseases. December 2007. [PDF, 645K]
Abnormalities of Body-Fat Distribution Chapter: Guide for HIV/AIDS Clinical Care
AIDS Education and Training Centers National Resource Center, 2014.
Provider Education and Training
Metabolic Complications Associated with the Treatment of HIV-Infected Persons
Fussa MJ, Paul Sindy M; Rutgers University Center for Continuing and Outreach Education; June 2008. An online learning activity designed for physicians, nurses, and other health care professionals involved in the care of persons with HIV/AIDS. Also available in PDF format.
Slide Sets
Metabolic Complications of HIV
Haelel L; New York/New Jersey AETC; December 2010. [PowerPoint, 2.25MB]
Metabolic Complications of HIV Infection and Antiretroviral Therapy
Northwest AETC; 2006. [PowerPoint, 9.5MB]
Links
HIV-Specific
AIDSinfo Drug Database
U.S. Department of Health and Human Services (DHHS) project providing information on antiretroviral treatment and drugs that treat or prevent AIDS-related illness.
AIDSmeds.com
Succinct, easy-to-read information on HIV drugs and related issues.
Anti-HIV Compounds Database
Computerized databases containing chemical structures and biological data established at the Division of AIDS (DAIDS) of NIAID to foster developments in the chemotherapy of HIV and opportunistic infections and to serve as an information source.
Database of Antiretroviral Drug Interactions
Search by antiretroviral drug, interacting drug, or interacting drug class. Maintained by HIV InSite.
FDA Office of Special Health Issues, HIV/AIDS Activities
Information on HIV/AIDS drugs, State AIDS Fraud Task Forces, articles, brochures, and useful tables.
hiv-druginteractions.org
Site features information on interactions with each class of antiretroviral drugs. Maintained by the Liverpool HIV Pharmacology Group, University of Liverpool.
HIV Medication Guide
Features information on single- and multiple-HIV drug interactions, a customizable medication chart function, patient drug pamphlets, and more. Available in English and French from JAG enterprises, a clinical pharmacy consultation firm.
Johns Hopkins HIV Guide
An on-line decision support tool designed to assist clinicians in the diagnosis, management and treatment of HIV/AIDS. Requires registration.
NIAID/DAIDS: HIV/AIDS Treatment
An easy-to-read site with a comprehensive overview of the discovery and development of AIDS therapeutics, from the Division of AIDS (DAIDS) of the National Institute of Allergy and Infectious Diseases (NIAID).
Toronto General Hospital Immunodeficiency Clinic
HIV treatment resources, including drug interactions tables, fact sheets, and other information for health care professionals.
General
Clinical Pharmacology
Up-to-date, peer reviewed, clinically-relevant information on all U.S. drugs, as well as off-label uses and dosages, herbal supplements, nutritional products, and new and investigational drugs. Requires paid subscription.
Cytochrome P450 Drug Interaction Table
Designed as a hypothesis testing, teaching, and reference tool for physicians and researchers interested in drug interactions that are the result of competition for, or effects on the human cytochrome P450 system. Includes links to canned PubMed searches.
FDA Center for Drug Evaluation and Research
(CDER) Reports and information on prescription and over-the-counter drugs, as well as regulatory issues and the drug approval process, public health alerts, and more.
PDR.net
Physicians' Desk Reference online, featuring drug and healthcare information, with separate interfaces for physicians, pharmacists, physician assistants, nurses, and consumers. Registration is required, and is either free or fee-based, depending on the level of access desired.
RxList
Index of information on pharmaceutical products from WebMD. Features search function for looking up drugs by the pill imprint code.
Adverse Event Reporting and Emergencies
American Association of Poison Control Centers
List of poison control centers.
Antiretroviral Pregnancy Registry
Intended to provide an early signal of any major teratogenic effect associated with a prenatal exposure to the products monitored through the registry, a voluntary prospective, exposure-registration, observational study designed to collect and evaluate data on the outcomes of pregnancy exposures to antiretroviral products.
MedWatch
FDA safety information and adverse event reporting program for drugs and other medical products.
U.S. Pharmacopeial Convention
A scientific nonprofit organization that sets standards for the identity, strength, quality, and purity of medicines, food ingredients, and dietary supplements manufactured, distributed and consumed worldwide.
Vaccine Adverse Event Reporting System
(VAERS) Vaccine surveillance program of the FDA Center for Biologics Evaluation and Research.