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Molecular Insights Into HIV Biology: Related Resources
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Related Knowledge Base Chapters
Structure, Expression, and Regulation of the HIV Genome
Thomas J. Hope, Didier Trono; November 2000.
Journal Articles
Combinatorial RNA-based gene therapy for the treatment of HIV/AIDS
Chung J, DiGiusto DL, Rossi JJ. Expert Opin Biol Ther. 2013 Mar;13(3):437-45.
The split personality of regulatory T cells in HIV infection
Chevalier MF, Weiss L. Blood. 2013 Jan 3;121(1):29-37.
Macrophages and their relevance in human immunodeficiency virus type I infection
Koppensteiner H, Brack-Werner R, Schindler M. Retrovirology. 2012 Oct 4;9:82.
The structural biology of HIV-1: mechanistic and therapeutic insights
Engelman A, Cherepanov P. Nat Rev Microbiol. 2012 Mar 16;10(4):279-90.
HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation
Chomont N, El-Far M, Ancuta P, et al. Nat Med. 2009 Jun 21; Epub ahead of print. [PDF]
HIV-1 dynamics: a reappraisal of host and viral factors, as well as methodological issues
Prentice HA, Tang J. Viruses. 2012 Oct 10;4(10):2080-96.
Conference Reports and Proceedings
Basic Science Summary
Mario Stevenson. Topics in Antiviral Medicine, International Antiviral Society-USA, April/May 2013. Highlights of the 20th Conference on Retroviruses and Opportunistic Infections; Atlanta; March 3-6, 2013. [PDF, 124K]
The Cell Biology of HIV-1 and Other Retroviruses
Eric O. Freed, Andrew J. Mouland. Retrovirology, 2006; 77(3). American Society for Cell Biology Summer Conference; Emory University, Atlanta, GA; July 20-23, 2006. [PDF, 444K]
Presentations, Interviews, and Roundtable Discussions
Quantitative 3D Video Microscopy of HIV Transfer Across T Cell Virological Synapses
Hubner W, McNerney GP, Chen P, et al. Science. 27 March 2009; 323 (5922):1743 - 1747. [Video]
Online Books and Chapters
HIV Sequence Compendium 2012
Kuiken C, Foley B, Marx P, et al. Published by Theoretical Biology and Biophysics, Los Alamos National Laboratory, LA-UR 09-03280.
John M. Coffin, Stephen H. Hughes, Harold E. Varmus, Cold Spring Harbor Laboratory Press; c1997.
HIV Replication Cycle
National Institute of Allergy and Infectious Disease (NIAID), 2012.
Simplified representation of HIV lifecycle
A graphical overview of HIV infection, starting with the virus interacting with cell surface receptors, then incorporating its genome into the host DNA, and ultimately transforming to the mature infectious form capable of fusing with a new susceptible cell. EMBL. 2009.
Patient and Community Education
Biology of HIV
An overview of basic HIV biology written for a lay audience.
National Institute of Allergy and Infectious Diseases.
Molecular Biology of HIV-1: Regulatory Genes
Gatignol A, McGill University; March 2007. [PDF]
HIV Life Cycle - Animations:
bullet.gifThe Life Cycle of HIV, a Retrovirus
Perry, et al., Microbial Life, First Edition. 2002. [Adobe Flash]
Created by Jim Sullivan.
HIV and Antiretroviral Drugs - Animations:
bullet.gifAnti-HIV Therapy
Bless Castro, PhD, and Laurence Peiperl, MD. The structure, life cycle, and pathogenesis of HIV, and the function of antiretroviral drugs. Animated Flash educational course with audio, produced by GeneEd and HIV InSite. Full running time is 30 minutes, but course may also be viewed in sections.
HIV Databases
The HIV databases contain data on HIV genetic sequences, immunological epitopes, drug resistance-associated mutations, and vaccine trials. The website also gives access to a large number of tools that can be used to analyze these data. Produced by Los Alamos National Laboratory and funded by NIAID.