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Updates to the Database of ARV Drug Interactions

The following table summarizes recent additions to the HIV InSite Database of Antiretroviral Drug Interactions.For a full description of the updates, including references to the studies from which the data were derived, go to the database, click on a specific drug name, and search for the interacting agent.

New ARV Interactions (January-April 2012)
Drug OneDrug TwoClinical EffectsMechanismsManagement
Source: McNicholl I. HIV InSite Database of Antiretroviral Drug Interactions. University of California San Francisco: Center for HIV Information; 2012.
AtazanavirBoceprevirDecreased HIV treatment efficacyDo not coadminister
DarunavirBoceprevirDecreased HIV and HCV treatment efficacyDo not coadminister
DarunavirBeclomethasoneNo dosage adjustment necessary
DarunavirPravastatinNo dosage adjustment necessary
Lopinavir/ritonavirBoceprevirDecreased HIV and HCV treatment efficacyDo not coadminister
NevirapineLumefantrinePotentially increased treatment failureDo not coadminister; avoid arthemether/lumefantrine in patients receiving nevirapine if at all possible
NevirapineArtemetherPotentially increased treatment failureDo not coadminister; avoid arthemether/lumefantrine in patients receiving nevirapine if at all possible
RaltegravirBoceprevirNo dosage adjustment necessary
RaltegravirRilpivirineNo dosage adjustment necessary
RaltegravirRifapentineDosage adjustment not established
RitonavirBeclomethasoneUse lowest possible dosage and titrate to effect