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Home > Treatment > HIV Meds Quarterly > Spring 2009 > Updates to the Database
Updates to the Database of ARV Drug Interactions
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The following table summarizes recent additions to the HIV InSite Database of Antiretroviral Drug Interactions. For a full description of the updates, including references to the studies from which the data were derived, click on a specific drug name in the table below and search for the interacting agent.

New ARV Interactions (January-April 2009)
Drug OneDrug TwoClinical EffectsMechanismsManagement
Source: McNicholl I. HIV InSite Database of Antiretroviral Drug Interactions. University of California San Francisco: Center for HIV Information; 2009
RaltegravirAtazanavirPossibly ↑ raltegravir effectsDosage adjustment not established
NevirapineFluconazolePossibly ↑ increased nevirapine effectsInhibition of CYP450 3A4 by fluconazoleNo dosage adjustment necessary
AtazanavirSimvastatin↑ simvastatin effects (eg, myopathy, rhabdomyolysis)Inhibition of CYP450 3A4 by atazanavirDo not coadminister

Alternative agents:
Atorvastatin (low dose); pravastatin
EfavirenzPosaconazole↓ posaconazole effectsInduction of UDP-G by efavirenzAvoid coadministration if possible
RitonavirPosaconazole↑ ritonavir effectsInhibition of CYP450 3A4 by posaconazoleMonitor closely for adverse effects during coadministration
AtazanavirPosaconazole↑ atazanavir effectsInhibition of CYP450 3A4 by posaconazoleMonitor closely for adverse effects during coadministration
Atazanavir/ritonavirPosaconazole↑ atazanavir effectsInhibition of CYP450 3A4 by posaconazoleMonitor closely for adverse effects during coadministration
Lopinavir/ritonavirPrednisonePossibly ↑ prednisolone effectsNo dosage adjustment necessary
EfavirenzPrednisonePossibly ↑ prednisolone effectsNo dosage adjustment necessary

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