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HIV Infection and Metabolic Bone Disease
Slide 1.
HIV Infection and Metabolic Bone Disease
Slide 1.
HIV and Bone Disease
Slide 2.
Topics
Slide 3.
Osteoporosis
Slide 4.
Aging: Male vs Female Skeleton
Slide 5.
Figure 1: Bone Mass Lifecycle
Slide 6.
Fracture Incidence: Men vs Women
Slide 7.
Hip Fractures Are Associated with Increased Morbidity and Mortality
Slide 8.
Survival after Hip Fracture
Slide 9.
BMD Measurements -- DXA
Slide 10.
BMD Measurements -- DXA
Slide 11.
Clinical Risk Factors for Osteoporotic Fractures
Slide 12.
Age and Fracture Risk vs BMD in the General Population
Slide 13.
FRAX: WHO Algorithm for Absolute Fracture Risk
Slide 14.
FRAX: Calculating 10-Year Fracture Probability
Slide 15.
NOF -- "Clinician's Guide to Prevention and Treatment of Osteoporosis" (2008)
Slide 16.
NOF -- "Clinician's Guide to Prevention and Treatment of Osteoporosis" (2008) (cont'd)
Slide 17.
Vitamin D: Production and Metabolism
Slide 18.
The 25(OH)D Continuum Controversy
Slide 19.
Why Do We Lose Bone Mass with Menopause and Normal Aging? (and with HIV Infection)
Slide 20.
Bone Mass -- Remodeling
Slide 21.
Slide 22
Slide 22.
HIV and Bone
Slide 	23.
#1 -- What Is the Epidemiology of Low BMD in HIV-Infected Patients and Are They at Greater Risk of Fractures?
Slide 24.
Metaanalysis of 11 Cross-Sectional Studies (Brown and Qaqish, AIDS 2006)
Slide 25.
Metaanalysis of 7 Cross-Sectional Studies
Slide 26.
Metaanalysis of 12 Cross-Sectional Studies (Brown and Qaqish, AIDS 2006)
Slide 27.
Caveats of Metaanalyses (Brown and Qaqish, AIDS 2006)
Slide 28.
Fracture Prevalence in HIV-Infected Patients (N = 8,525) vs Noninfected Controls (N = 2.2 million): Partners Health Care System (Retrospective)
Slide 29.
Fracture Prevalence in HIV-Infected vs Noninfected Controls
Slide 30.
#2 -- What Are Special Risk Factors for Bone Loss?
Slide 31.
What Are Special Risk Factors for Bone Loss? (cont'd)
Slide 32.
Role of Specific ART in Bone Loss -- Controversial
Slide 33.
Role of Specific ART in Bone Loss -- Controversial
Slide 34.
#3 -- What Is the Vitamin D Status of HIV-Infected Patients?
Slide 35.
What Is the Vitamin D Status of HIV-Infected Patients? (cont'd)
Slide 36.
What Is the Vitamin D Status of HIV-Infected Patients? (cont'd)
Slide 37.
#4 -- Who Should Be Screened for Low BMD?
Slide 38.
Who Should Be Screened for Low BMD? (cont'd)
Slide 39.
#5 -- When Should Treatment Be Started and What Treatment Works?
Slide 40.
When Should Treatment Be Started and What Treatment Works? (cont'd)
Slide 41.
Conclusions
Slide 42.

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