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Regimen Simplification
Slide Presentation
December 10, 2010
Monica Gandhi, MD, MPH

Click on slide thumbnails to view full-size image.

Slide 1.
Regimen Simplification
Slide 1.
Financial Disclosure
Slide 2.
Case #1
Slide 3.
Case #1 Continued
Slide 4.
Slide 5
Slide 5.
ARS Question: Which HAART Regimen Would You Have Started in This Patient in 2005?
Slide 6.
This Is How I Thought about It
Slide 7.
Case #1 (Cont)
Slide 8.
ARS Question: Which Regimen Would You Simplify The Patient To Now?
Slide 9.
Why Simplify?
Slide 10.
Why Simplify?
Slide 11.
Simplifying to One Pill Daily
Slide 12.
Let's Go Back to Our Question For Case #1 - Which Regimen Would You Simplify The Patient to Now?
Slide 13.
This Is How I Thought about It
Slide 14.
Answer 2: Simplify to Raltegravir
Slide 15.
ARS Question: What Were The Results of Simplification Trials From LPV/r to Raltegravir?
Slide 16.
SWITCHMRK Trials 1, 2
Slide 17.
Who Failed on RAL in SWITCHMRK?
Slide 18.
Answer 3: Simplify to Etravirine?
Slide 19.
Etravirine Weighted Genotype Score to Predict Response
Slide 20.
Relation Between The Weighted Mutation Score & Virologic Response (<50 cp/ml)
Slide 21.
Answer #3: Simplify to Maraviroc?
Slide 22.
Case #2
Slide 23.
ARS Question: Which PI Simplification Strategy Is Best Studied for Lipid Improvement?
Slide 24.
Simplifying to Atazanavir for Lipid Control
Slide 25.
Case#2 Continued
Slide 26.
ARS Question: Is There Another Simplification Strategy You Can Use for Her Hyperbilirubinemia?
Slide 27.
This Is How I Thought about It
Slide 28.
Once Daily vs BID Raltegravir
Slide 29.
ARIES Simplification Trial Study
Slide 30.
HIV-1 RNA <50 copies/mL (ITT-E, TLOVR)
Slide 31.
Case #3
Slide 32.
Case #3 Continued
Slide 33.
ARS Question: At Which Age Do You Screen The HIV-Infected Men In Your Practice for Bone Mineral Density?
Slide 34.
Case #3 Continued
Slide 35.
Remember Our Definitions
Slide 36.
Ars Question: Would You Switch Patient Off TFV at This Point?
Slide 37.
Case #3 Continued
Slide 38.
ARS Question: Which Regimen Would You Choose Next for Mr. S?
Slide 39.
This Is How I Thought about It
Slide 40.
Nucleoside-Sparing Regimens
Slide 41.
Monotherapy with Boosted PIs
Slide 42.
Monotherapy with DRV/r
Slide 43.
Nuc Sparing Strategies
Slide 44.
Stop AIDS. Make The Promise
Slide 45.

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