Slides: The AIDS Vaccine Challenge

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Slides: The AIDS Vaccine Challenge

Slide Presentation
December 1, 2005

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Slide 1.

The AIDS Vaccine Challenge

Slide 1.

HIV/AIDS: Global Threat to Nations

Slide 2.

The virus

Slide 3.

HIV-1 Envelope gp120

Slide 4.

HIV: Cell Entry

Slide 5.

Initial HIV Infection

Slide 6.

Seminal Fluid

Slide 7.

Micrograph

Slide 8.

HIV Replication Permits Genetic Mutations

Slide 9.

HIV Transmission

Slide 10.

The Cervix

Slide 11.

Vaginal and Cervical cells

Slide 12.

Tissues with Virus-infected Cells after Intravaginal SIV Inoculation

Slide 13.

How Can the Immune System Control HIV Transmission?

Slide 14.

Innate Immunity - Adaptive Immunity

Slide 15.

Comparative Immune Systems

Slide 16.

Innate Immune Systems

Slide 17.

Adaptive Immune Systems

Slide 18.

CD8+ Cell Antiviral Activity

Slide 19.

CD8+ Cells Block HIV Replication

Slide 20.

Importance of the Innate Immune System in HIV Vaccine Development

Slide 21.

Innate Immunity-Cytokines-Responses

Slide 22.

Overally Objective of an AIDS Vaccine

Slide 23.

The Ideal HIV Vaccine

Slide 24.

An HIV Vaccine is Possible

Slide 25.

Slide Not Available

Slide 26.

Challenges of Developing an HIV Vaccine

Slide 27.

The AIDS Viruses

Slide 28.

Geographic Distribution of HIV-1 Subtypes and HIV-2

Slide 29.

HIV Vaccine Approaches

Slide 30.

Vectors Evaluated for HIV Vaccines

Slide 31.

Prime-Boost

Slide 32.

Effective HIV Immunization

Slide 33.

Human Clinical Vaccine Trials

Slide 34.

Key Requirements for HIV Vaccine Trials

Slide 35.

HIV Vaccine Trials Network Clinical Sites, 2005

Slide 36.

Clinical Trials of Preventive HIV Vaccines

Slide 37.

Timeline for Phase III Vaccine Trials held in Canada, Puerto Rico, the Netherlands, and the United States

Slide 38.

Factors Involved in the Completion of Two Phase III Vaccine Trials

Slide 39.

What is the Shortest Time Vaccine Development Could Take?

Slide 40.

Development of Licensed Vaccines

Slide 41.

Some of the Major Stakeholders in HIV Vaccine Research

Slide 42.

Companies Involved in HIV Vaccine Development

Slide 43.

Companies Involved in HIV Vaccine Development

Slide 44.

Newest HIV Vaccine Efficacy Trial

Slide 45.

ARI TAG Vaccine Group

Slide 38.

HIV Vaccine Research in Northern California

Slide 39.

The Value of Baboon Models in Evaluating HIV Vaccines

Slide 40.

Baboon HIV-2 DNA Immunizations

Slide 41.

Three Week PBMC Viral Load* in HIV-2 Vaccinated Baboons

Slide 42.

HIV Vaccine Research and Design Program (HIV/RAD)

Slide 43.

Importance of the Innate Immune System

Slide 44.

Potential Value of Transgenic Plants in Vaccine Development

Slide 45.