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Slides: The AIDS Vaccine Challenge
Slide 1.
The AIDS Vaccine Challenge
Slide 1.
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HIV/AIDS: Global Threat to Nations
Slide 2.
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The virus
Slide 3.
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HIV-1 Envelope gp120
Slide 4.
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HIV: Cell Entry
Slide 5.
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Initial HIV Infection
Slide 6.
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Seminal Fluid
Slide 7.
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Micrograph
Slide 8.
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HIV Replication Permits Genetic Mutations
Slide 9.
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HIV Transmission
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The Cervix
Slide 11.
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Vaginal and Cervical cells
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Tissues with Virus-infected Cells after Intravaginal SIV Inoculation
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How Can the Immune System Control HIV Transmission?
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Innate Immunity - Adaptive Immunity
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Comparative Immune Systems
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Innate Immune Systems
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Adaptive Immune Systems
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CD8+ Cell Antiviral Activity
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CD8+ Cells Block HIV Replication
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Importance of the Innate Immune System in HIV Vaccine Development
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Innate Immunity-Cytokines-Responses
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Overally Objective of an AIDS Vaccine
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The Ideal HIV Vaccine
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An HIV Vaccine is Possible
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Slide Not Available
Slide 26.
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Challenges of Developing an HIV Vaccine
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The AIDS Viruses
Slide 28.
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Geographic Distribution of HIV-1 Subtypes and HIV-2
Slide 29.
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HIV Vaccine Approaches
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Vectors Evaluated for HIV Vaccines
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Prime-Boost
Slide 32.
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Effective HIV Immunization
Slide 33.
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Human Clinical Vaccine Trials
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Key Requirements for HIV Vaccine Trials
Slide 35.
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HIV Vaccine Trials Network Clinical Sites, 2005
Slide 36.
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Clinical Trials of Preventive HIV Vaccines
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Timeline for Phase III Vaccine Trials held in Canada, Puerto Rico, the Netherlands, and the United States
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Factors Involved in the Completion of Two Phase III Vaccine Trials
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What is the Shortest Time Vaccine Development Could Take?
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Development of Licensed Vaccines
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Some of the Major Stakeholders in HIV Vaccine Research
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Companies Involved in HIV Vaccine Development
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Companies Involved in HIV Vaccine Development
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Newest HIV Vaccine Efficacy Trial
Slide 45.
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ARI TAG Vaccine Group
Slide 38.
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HIV Vaccine Research in Northern California
Slide 39.
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The Value of Baboon Models in Evaluating HIV Vaccines
Slide 40.
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Baboon HIV-2 DNA Immunizations
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Three Week PBMC Viral Load* in HIV-2 Vaccinated Baboons
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HIV Vaccine Research and Design Program (HIV/RAD)
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Importance of the Innate Immune System
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Potential Value of Transgenic Plants in Vaccine Development
Slide 45.
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