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Transplantation in HIV-positive patients
Slide 1.
Overview
Slide 1.
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Evolution of the Issues
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Kidney Study 1
Slide 3.
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Kidney Study 2
Slide 4.
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Kidney Study 2: Results
Slide 5.
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Liver Study 1
Slide 6.
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HCV in HIV+ and Negative Recipients
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HCV in HIV+ and Negative Recipients
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Kidney & Liver Study 1
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Deaths
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Opportunistic Complications
Slide 11.
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Results: Outcomes
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Outcomes: Ineligible Subjects
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Conclusions
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Kidney & Liver Study 2
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Table 1. Baseline Characteristics of HIV-Infected Transplant Recipients
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Patient Survival
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Cause of Death
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Graft Survival
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Graft Loss (Censored for death)
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Table 2. Patient and Graft Survival in HIV-Infected Study Subjects and in the Organ Procurement and Transplantation Network (OPTN) Database
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HIV Disease Progression Post-TX
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Allograft Rejection
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Kidney Function
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Acute rejection
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Conclusions
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Drug Interactions
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Drug Interactions
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Changes in CsA clearance over time in patients using PIs vs NNRTIs
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Consquences of Rejection (N=20 kidney)
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CD4 Counts in HIV-infected Kidney Recipients
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Infections
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Multi-Disciplinary Health Care Team
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Pretransplant Survival Is Shorter in HIV-Positive Than HIV-Negative Subjects With End-Stage Liver Disease
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HIV Solid Organ Transplant Mult-Site Study
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Participating Centers: Solid Organ Transplantation in HIV: Multi-Site Study
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The Experience
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Criteria for Transplant
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Referral for Kidney Transplant
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Referral for Liver Transplant
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MELD Score
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Kidney Evaluation: Initial Process
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Liver Evaluation: Initial Process
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Medical Workup
Slide 44.
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Psychosocial, Financial, & Social Support Evaluation
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Organ Allocation
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Pre Transplant Challenges
Slide 47.
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Factors that Influence Waiting Time
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The Waiting...
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Reality
Slide 50.
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Post Transplant Challenges
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Challenge: Physical Complications
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Challenge: Clinical Trial
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Challenge: Psychiatric
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Conclusion
Slide 55.
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