Issues in CNS HIV Infection

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Issues in CNS HIV Infection

Slide Presentation
March 1, 2006
Richard Price, MD

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Slide 1.

Issues in CNS HIV Infection - A View of CNS Infection through the LP Needle

Slide 1.

Issues in CNS HIV Infection: Outline

Slide 2.

Review: AIDS Dementia Complex and HIV Encephalitis

Slide 3.

AIDS Dementia Complex (ADC), a Syndrome of Cognitive-Motor Dysfunction

Slide 4.

ADC: Multinucleated-Cell (HIV) Encephalitis

Slide 5.

ADC: Vacuolar Myelopathy

Slide 6.

MRI in ADC: 'HIV Enephalopathy'

Slide 7.

Effect of ART on CNS Disease Prevention

Slide 8.

Effect of Treatment on CNS Diseases

Slide 9.

Essential View of Brain Injury Pathogenesis: Principal Agonists

Slide 10.

CSF as a Window into CNS HIV

Slide 11.

CSF Window on CNS HIV Infection

Slide 12.

Origins of CSF Contents

Slide 13.

Character of CSF HIV Infection

Slide 14.

Relation of CSF HIV to Blood CD4+

Slide 15.

Relation of CSF HIV to Plasma HIV

Slide 16.

Models of CSF HIV Infection

Slide 17.

Compartment CCR Utilization: Concordance and Discordance of Plasma and CSF HIV Populations

Slide 18.

(no title)

Slide 19.

Effects of Treatment on CSF HIV

Slide 20.

CSF HIV Response to ART

Slide 21.

ART Effects: Relation of CSF to Plasma Response

Slide 22.

ART Effects on CSF HIV

Slide 23.

CSF Responses to ART

Slide 24.

'Disproportional' Effect of ART on CSF HIV in Experienced Subject

Slide 25.

ART Effects on CSF: Reduction of Intrathecal Immunoactivation

Slide 26.

Application of Flow Cytometry to CSF

Slide 27.

CSF Cell Composition by Flow Cytometry

Slide 28.

CSF T Cell Activation

Slide 29.

'Disproportionate' CSF Response to ART: Hypotheses

Slide 30.

Plasma:CSF HIV Gradient

Slide 31.

CSF NFL: A Marker of Brain Injury

Slide 32.

Neurofilament Protein Light Chain (NFL)

Slide 33.

CSF Neurofilament Protein in HIV

Slide 34.

NFL Responses to ART in ADC Patients

Slide 35.

NFL Response to ART in ADC Patient

Slide 36.

Effects of ART interruption on CSF HIV and NFL

Slide 37.

CSF NFL in HIV Infection: Some Possible Implications

Slide 38.

Closing Remarks

Slide 39.

Cerebrospinal Fluid (CSF) in HIV Infection: Themes

Slide 40.

CNS HIV Infection: Unresolved Clinical Issues

Slide 41.

Acknowledgements

Slide 42.

LP Headaches: 1996-2006 (Feb)

Slide 43.