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HPV Infection in HIV-Seropositive Men and Women
Slide Presentation
January 9, 2008
Joel Palefsky, MD

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Slides may be used only with author permission.

Slide 1

HPV Infection in HIV-Seropositive Men and Women
Slide 1

Estimated Annual Burden of HPV-Related Diagnoses in the United States
Slide 2

HPV
Slide 3

HPV Infection and Productive Life Cycle
Slide 4

General Organization of a Papillomavirus Genome
Slide 5

E6 Leads to Degradation of p53
Slide 6

DNA Repair Enzymes
Slide 7

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Slide 8

From Condyloma to Cancer
Slide 9

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Slide 10

Age-Standardized Cervical Cancer Incidence
Slide 11

Natural History of Cervical Neoplasia
Slide 12

Percent with Cervical HPV Infection
Slide 13

Features of Cervical HPV Infection Unique to HIV+ Women
Slide 14

Percent with Abnormal Cervical Cytology
Slide 15

Clinical Challenges in HIV+ Women
Slide 16

Guidelines for Assessment of CIN in HIV+ Women
Slide 17

Anal and Cervical Cancer Incidence
Slide 18

Relative Risk of Anal Cancer in U.S. AIDS-Cancer Registry Match Study*
Slide 19

Illustration of Rectum and Anus
Slide 20

Perianal Bowen's Disease
Slide 21

Perianal SISCCA
Slide 22

Rectal Exam
Slide 23

Cervical Culposcope Being Used for Anascopy
Slide 24

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Slide 25

Anal Warts
Slide 26

Intra-Anal SISCCA
Slide 27

Diagnosis of AIN/Anal Cancer
Slide 28

Percent with Anal HPV Infection
Slide 29

Percent with Abnormal Anal Cytology
Slide 30

Anal and Cervical HPV Infection in HIV-Positive Women
Slide 31

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Slide 32

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Slide 33

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Slide 34

Anal Cancer Since Introduction of HAART
Slide 35

San Francisco AIDS Surveillance Registry- California Cancer Registry Match
Slide 36

Who should be screened?
Slide 37

Anal cytology screening for AIN in MSM
Slide 38

The big question:
Slide 39

U.S. anal screening guidelines
Slide 40

New York State Department of Public Health AIDS Institute Guidelines: Primary Care Approach To The HIV-Infected Patient
Slide 41

Treatment of AIN
Slide 42

Benefits of Anal Screening
Slide 43

HPV Prophylactic Vaccines
Slide 44

HPV L1 Protein Self-Assembles Into VLPs1?3
Slide 45

Immune Response to HPV Vaccines
Slide 46

Immune Response to HPV Vaccines
Slide 47

Immune Response to HPV Vaccines
Slide 48

Quadrivalent HPV Vaccine
Slide 49

Quadrivalent Vaccine
Slide 50

Phase II Bivalent Vaccine
Slide 51

Issues to Consider with HPV Vaccination of HIV+ Men and Women
Slide 52

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