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Interesting Cases in HIV Clinical Pharmacology
Slide 1.
Interesting Cases in HIV Clinical Pharmacology
Slide 1.
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Drug Interaction Primer
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Pharmacokinetic Parameters
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Metabolism
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Cytochrome P450
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Proportion of Drugs Metabolized by CYP450 Enzymes
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Role of P-glycoprotein
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Types of Drug Interactions
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Types of Drug Interactions P450 3A4 Substrates
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P450 3A4 Substrates Recreational Drugs
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Types of Drug Interactions P450 3A4 Induction
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Examples of Induction
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Types of Drug Interactions P450 3A4 Inhibition
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Sildenafil and PI Interactions
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PDE5 Inhibitor Comparison
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Examples of Inhibition
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Slide 20
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Case 1
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Case 1
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FDA-Approved H. pylori Treatment Regimens
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Proton Pump Inhibitor Comparison
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Results ATV and Omeprazole
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H2-Blocker Comparison
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Pharmacokinetic Summary ATV and famotidine
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Amprenavir PK
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Effects of Acid Reduction on PI Pharmacokinetics
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Case 2
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Case 2
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Case 2
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Rosuvastatin (Crestor)
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Rosuvastatin
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Case 3
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Case 3
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ACTG A5047 Statin Interaction with PIs
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Anti-lipidemics and PIs
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Major Risk Factors That Modify LDL Goals
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CVD Risk Factors
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LDL Goals for Therapeutic Lifestyle Changes and Drug Therapy
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Drug Therapy
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Statin Comparison, Efficacy and Dosing
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Case 3
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PROVE IT TIMI 22 (2-Year Trial)
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Clinical Relevance of Achieved LDL-C and Achieved CRP after Treatment with Statin Therapy: PROVE IT TIMI 22
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Case 3
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Ezetimibe (Zetia)
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Ezetimibe Efficacy as Add-On Therapy
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Investigational Agents
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Nucleoside/tide RTIs
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Non-nucleoside RTIs
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Protease inhibitors
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TPV/r Drug Interactions
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Classes of Entry Inhibitors
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CCR5 Inhibitors in Development
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1 Minute Counsel
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1 Minute Counsel
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Summary
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Slide 66
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Questions?
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