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Lessons from Primary HIV Infection
Slide 1.
Lessons From Primary HIV Infection
Slide 1.
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A Tale of Two Patients
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Donald
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Dick and Donald Compare Notes
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Dick and Donald Compare Notes
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Dick and Donald Compare Notes
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Dick and Donald Compare Notes
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Dick and Donald Compare Notes
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Dick and Donald Want to Know
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Symptomatic Acute HIV
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Options Project Analysis of Acute HIV Symptoms and Viral Load
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Relationship of Number of Symptoms to Initial Viral Load
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Univariate and Multivariate Mixed Model to Predict Set Point Viral Load
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Univariate and Multivariate Mixed Model to Predict Set Point Viral Load
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How Important Is the Viral Load Set Point in Predicting Disease Progression?
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MACS: Progression to AIDS by Viral RNA and CD4 after Seroconversion
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MACS: Progression to AIDS by Viral RNA and CD4 after Seroconversion
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Conclusions
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Why Is Donald's Viral Load Higher?
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HLA Matters: Risk of Progression to AIDS Based on HLA Score in MACS
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HLA Predicts Early Viral Load
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HLA Molecule Presents Antigens to T-cells
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HLA Molecule Binds Specific Peptides Restricted by HLA-Type
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CTL Escape Mutations
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HIV Requires Co-Receptors for Cell Entry
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CCR5 Receptor Genetics and Ligand Copies Predict VL
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Is It All about the Host?
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Transmission Pairs
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Viral Load in Source Predicts
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Summary of Derminants of Viral Load
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Is All about Viral Load?
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Estimated Annual CD4 Cell Count Loss in Untreated HIV-Infected Patients According to Presenting Plasma HIV RNA Level
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Histograms of CD4 Cell Count Change by Categories of Presenting Plasma HIV RNA Level Among All Patients in the Study Cohort
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Predictors of the Rate of Progression to AIDS in MACS
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Predictors of the Rate of Progression to AIDS in MACS
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Predictors of the Rate of Progression to AIDS in MACS
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CD4 T-cell Decline Differs according to T-cell Activation
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Mixed Effects Regression Assessing the Predictors of CD4 T-cell Count Over Time
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Summary of CD4+ T-cell Loss
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Should Dick and Donald be Treated?
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Mass General Acute HIV STI Study
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Mass General Cohort
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Remaining Questions
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Reconstitution of Mucosal CD4+ T cell Depletion?
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AIEDRP Observational Treatment Analysis
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Analysis
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Untreated VS Acute Tx VS Early Tx Viral load
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Viral Load Results
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Viral Load Results
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CD4+ T-cell Results
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CD4+ T-cell Results
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Conclusions
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Viral Load During Treatment Interruption
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IFNy ELISPOT Results
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Gag p24 and p17 Amino Acid Sequence
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Final Conclusion
Slide 56.
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