An Update on Clinical Trials of Preventive HIV Vaccines
Overview
11,000 New Infections a Day in 2006
Why a Vaccine to Prevent HIV?
How Long It Takes to Develop Effective Vaccines
Reasons for Optimism
The Goals of a Preventive HIV Vaccine
Possible Mechanisms for Vaccine-Induced Protective Immunity
The Level of HIV in the Blood Stream Predicts Subsequent Survival
Can a Vaccine Reduce the Viral Set Point?
Plasma VL and Risk of Transmission in an Untreated Ugandan Community Study
Vaccine Approaches in Clinical Trials
The Rise and Fall of Vaccine Approaches
Clinical Trials of Preventive HIV Vaccines
Safety Has Not Been the Problem
Few Adverse Events Are Related To Vaccine
Even When Related to Vaccine, Most Adverse Events Are Mild
Immunogenicity Disappointing, Part 1: Subunit Vaccines
Is This What We Will Have to Achieve?
VAX003: gp120 B/E' in IDU in Thailand
Immunogenicity Disappointing: Part 2 Canarypox
But Not All Pox-Based Vaccines Are Alike
Adenoviral Vectors
SHIV Challenge of Ad5-SIV gag Immunized Rhesus Monkeys
rAd5 Vector #1: MRKAd5 Trivalent Vaccine
MRKAd5 Trivalent gag/pol/nef
STEP Study Overview
Cross-Clade Reactivities: Ad5-Gag B Immunized Volunteers Can Recognize Clade A and C Gag Antigens
HVTN 503: Phambili
Multi-Gene, Multi-Clade DNA and rAd5 VRC Vaccines
Phase II Trials of VRC DNA/rAd5 Candidate HIV-1 Vaccine
PAVE 100
New Vaccine Vectors in Development
Upcoming Trials in San Francisco: Fall 2007
Requirements for Study Participation
Vaccine-Induced Antibody Positivity
HIV Western Blot
Mean Rate of HIV Tests per 1000 Patient-Visits in Persons Aged 18 Years or Older (December 2003-December 2006), San Francisco Department of Public Health Medical Care System