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An Update on Clinical Trials of Preventive HIV Vaccines
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An Update on Clinical Trials of Preventive HIV Vaccines
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Overview
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11,000 New Infections a Day in 2006
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Why a Vaccine to Prevent HIV?
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How Long It Takes to Develop Effective Vaccines
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Reasons for Optimism
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The Goals of a Preventive HIV Vaccine
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Possible Mechanisms for Vaccine-Induced Protective Immunity
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The Level of HIV in the Blood Stream Predicts Subsequent Survival
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Can a Vaccine Reduce the Viral Set Point?
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Plasma VL and Risk of Transmission in an Untreated Ugandan Community Study
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Vaccine Approaches in Clinical Trials
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The Rise and Fall of Vaccine Approaches
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Clinical Trials of Preventive HIV Vaccines
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Safety Has Not Been the Problem
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Few Adverse Events Are Related To Vaccine
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Even When Related to Vaccine, Most Adverse Events Are Mild
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Immunogenicity Disappointing, Part 1: Subunit Vaccines
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Is This What We Will Have to Achieve?
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VAX003: gp120 B/E' in IDU in Thailand
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Immunogenicity Disappointing: Part 2 Canarypox
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But Not All Pox-Based Vaccines Are Alike
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Adenoviral Vectors
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SHIV Challenge of Ad5-SIV gag Immunized Rhesus Monkeys
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rAd5 Vector #1: MRKAd5 Trivalent Vaccine
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MRKAd5 Trivalent gag/pol/nef
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STEP Study Overview
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Cross-Clade Reactivities: Ad5-Gag B Immunized Volunteers Can Recognize Clade A and C Gag Antigens
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HVTN 503: Phambili
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Multi-Gene, Multi-Clade DNA and rAd5 VRC Vaccines
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Phase II Trials of VRC DNA/rAd5 Candidate HIV-1 Vaccine
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PAVE 100
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New Vaccine Vectors in Development
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Upcoming Trials in San Francisco: Fall 2007
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Requirements for Study Participation
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Vaccine-Induced Antibody Positivity
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HIV Western Blot
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Mean Rate of HIV Tests per 1000 Patient-Visits in Persons Aged 18 Years or Older (December 2003-December 2006), San Francisco Department of Public Health Medical Care System
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Summary
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Acknowledgements
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Some Helpful Internet Resources
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HIV Vaccine Trials
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HIV Vaccine Trials
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Ad Campaign: HIV Vaccine Trials Unit
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Ad Campaign: SFisReady.org
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Ad Campaign: SFisReady.org
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Ad Campaign: SFisReady.org
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Ad Campaign: SFisReady.org
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Ad Campaign: SFisReady.org
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Ad Campaign: SFisReady.org
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Ad Campaign: project-embrace.org
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Ad Campaign: HelpFightHIV.org
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How You Can Help
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