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Androgen and Anabolic Therapies in HIV
Slide 1.
Androgen and Anabolic Therapies in HIV
Slide 1.
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Testosterone
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AIDS, Wasting, Hypogonadism
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Built to Survive
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Attention: Aging Men
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The Key to Great Sex
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Testosterone: Target Organs
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Production of Androgens from Cholesterol
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Production and Regulation of Testosterone
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Definition of Hypogonadism
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Causes of Hypogonadism
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Sustained-Action Oral Opioids
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Hypogonadism in the Aging Man
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Decreases in Plasma Testosterone Levels with Age
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Signs and Symptoms of Low Testosterone/Andropause
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Your penis shrinks 19.8% as you get older...
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Diagnostic Testosterone Testing: Initial Tests
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Diagnostic Testosterone Testing: Additional Tests
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Prevalence of Hypogonadism in HIV
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Controlled Trials of Testosterone Therapy in HIV+ Men
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Conflicting Reports on T's Effects
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IM Testosterone and/or Exercise In Eugonadal Men With AIDS Wasting
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IM Testosterone and/or Exercise In Eugonadal Men With AIDS Wasting
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IM Testosterone Therapy and Resistance Exercise in Hypogonadal HIV+ Men
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IM Testosterone Therapy and Resistance Exercise in Hypogonadal HIV+ Men
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Efficacy of TTD Patch (6 mg/day) in Treating HIV Hypogonadism/Wasting
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Efficacy of TTD Patch on HIV Hypogonadism (cont.)
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IM Testosterone In HIV-Associated Weight Loss
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IM Testosterone In HIV-Associated Weight Loss
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Testosterone Replacement and Mood Effects in Men Living With HIV
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Testosterone Replacement and Mood Effects in Men Living with HIV
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Goals and Benefits of Testosterone Replacement Therapy
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Testosterone Therapy Delivery Systems
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Testosterone Therapy Delivery Systems: Dosing and Administration
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Testosterone Enanthate 250mg Administered IM Every 3 Weeks
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Normal Secretory Total Serum Testosterone Profiles in Healthy Young and Older Men
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Testosterone (magazine cover)
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Testoderm TTS - Testosterone Transdermal System
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Testosterone Transdermal Patch Used on Nonscrotal Skin over 24 Hours
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Androgel (Testosterone gel)
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Testosterone Gel 1% Dosing
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Testosterone Therapy Delivery Systems: Adverse Effects
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Classification of Androgens
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Molecular Structures of Androgens in Clinical Use
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Structural-Potency Relationships of Commonly Used Anabolic-Androgenic Steroids (Animal Models)
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Nandralone in Dialysis Patients
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Nandralone in Dialysis Patients
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IM Anabolics in HIV
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Nandralone in Women with Weight Loss
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Oxandrolone Mechanism of Action
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Oxandrolone Trial: Preliminary Results from Baseline
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Anabolics and Body Habitus
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Monitoring Anabolic Steroid Therapy
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Anabolic Use in London Gyms
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Dehydroepiandrosterone and HIV: A Randomized Placebo-Controlled Study
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DHEA
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DHEA in the Testosterone Pathway
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Normal Function of DHEA
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DHEA Levels in HIV Infection
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DHEA and HIV Replication
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DHEA Trial Design
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DHEA Study Measurements
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DHEA Study Measurements
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DHEA Study
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Baseline Characteristics
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Baseline Characteristics
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Percent Change in Hormone Levels
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Estimated effects of DHEA on change in Log10 infectious units per million cells (mean and 95% CI)
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Effects of Immune Responsiveness
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DHEA Effects of Metabolism and Body Composition
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DHEA Affects on Mood and QOL
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DHEA and HIV: Conclusions
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Contraindications of Testosterone Replacement Therapy in Men
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Potential Risks of Testosterone Therapy
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Testosterone Therapy and Possible Prostate Changes
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Testosterone Use and Prostate Cancer
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Conclusions
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Major Unanswered Questions
Slide 80.
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