 | | Nevirapine (Viramune) |  | | Published
January 25, 2001; Updated
March 2013 | Susa Coffey, MD
http://hivinsite.ucsf.edu/InSite?page=ar-02-01 | | | Selected Reference | | 8. | León
A, Martinez
E, Mallolas
J, Laguno
M, Blanco
JL, Pumarola
T, Gatell
JM.
Early virological failure in treatment-naive HIV-infected adults receiving didanosine and tenofovir plus efavirenz or nevirapine. AIDS. 2005 Jan;19(2):213-5
[PubMed ID: 15668550]
| | | Abstract:
A 50% rate of early virological failure associated with the selection of resistance mutations was seen in a group of 14 antiretroviral-naive adults who initiated highly active antiretroviral therapy with tenofovir and didanosine plus efavirenz or nevirapine. At month 6, the mutations detected were K65R, L74V, L100I, K103N/R/T, Y181C and G190E/Q/S. These results argue against the use of tenofovir plus didanosine in HIV-infected antiretroviral-naive adults even when the third drug is a non-nucleoside reverse transcriptase inhibitor. | |
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